Milk Thistle — Beyond Conventional Cancer Therapies The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. In 2007, after reviewing numerous studies involving milk thistle therapeutic treatments, researchers at the University of Minnesota reported : Abstract. November 2016 in Health and wellbeing. Radiation-induced dermatitis is a common side effect of radiotherapy performed on cancer patients. 3. It's a great place to check supplements and so on. There are other studies that show silymarin is actually quite promising in both the prevention and possible therapeutic aid in breast cancer. The children taking milk thistle needed fewer chemotherapy dose reductions because of side effects than the children who did not take milk thistle. [1] " In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . Milk thistle is a plant that is native to Europe and was brought to North America by early colonists. Milk thistle is a plant whose fruit and seeds are used for liver and bile duct disorders. Milk thistle is usually taken in capsules or tablets. Silybum marianum is the scientific name for the plant commonly known as milk thistle. This is exactly why you should also use it, even though you are not the breastfeeding. However, the extracts in milk . Milk thistle is mainly a plant with long spiny leaves. Tag: milkThistle. 104-109 Advances in the Use of Milk Thistle (Silybum marianum) Janice Post-White, RN, PhD, FAAN, Elena J. Ladas, MS, RD, and Kara M. Kelly, MD Milk thistle (Silybum marianum) is an herbal supplement used to treat liver and biliary disorders. Milk thistle is now found throughout the eastern United States, California, South America . Laboratory studies have shown that milk thistle may have cancer-fighting properties. Milk thistle contains helpful antioxidants and may have anti-inflammatory properties. Milk Thistle in women increases the milk production. Milk thistle use has been reported in between 2% 23 and 7% 24,25 of cancer sufferers. 104 INTEGRATIVE CANCER THERAPIES 6(2); 2007 pp. The present study was designed to evaluate the effect of silymarin (Milk Thistle) in reducing the hepatic side effects of taxane when used in chemotherapy of breast cancer. Studies are ongoing. About the same time I started on Milk Thistle to help the liver but now have been reading it may not . Milk Thistle - Cancer Network Based on your unique information, Breastcancer.org can recommend articles that are highly relevant to your situation. In addition to blocking breast cancer, test-tube and animal studies show that silmarin may also protect against several other types of cancer as well, including lung cancer and prostate cancer. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). milk thistle can act like oestrogen in the body - if you have or are at risk of a hormone-related condition, including breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, speak to your doctor before using milk thistle Laboratory studies suggest that milk thistle or some of its compounds have protective effects on the liver, but other animal studies suggest negative effects when combined with chronic alcohol consumption. Just an aside on milk thistle - the medical establishment here in Portugal obviosuly acknowledges it works to detoxify the liver and to supprot the liver under strain.The human dose of milk thistle It was prescribed for my dog who had liver failure and when I read the leaflet, it said is was normally prescribed for human alcoholics undergoing detox. People with a history of hormone-related cancers, including breast, uterine, and prostate cancer, should not take milk thistle. Potential Health Benefits of Milk Thistle Milk Thistle (PDQ®)-Patient Version - National Cancer ... Milk Thistle Can Cure Psoriasis But It Is Very Estrogenic ... Methods This study was conducted on 99 patients with invasive breast carcinoma receiving chemotherapy contained adriamycin, epirubicin, cyclophosphamide, docetaxel, and . Studies of milk thistle have been done in acute lymphoblastic leukemia, prostate cancer, breast cancer, and head and neck cancer. The aim was to see if the silymarin gel could help prevent radiodermatitis (sore, inflammed skin caused by radiotherapy). Milk thistle is an herb that has been used for 2,000 years, most commonly for the treatment of liver and gallbladder disorders. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Breast Cancer Now is a company limited by guarantee registered in England (9347608) and a charity registered in England and Wales (1160558), Scotland (SC045584) and the Isle of Man (1200). Milk thistle: ''Silybum marianum,'' a member of the thistle family that traditionally has been used for its liver-protective properties. Milk thistle may also have anti-cancer properties because it's an antioxidant, and it could help people with diabetes. It says there's no interaction with milk thistle so it looks ok. Milk thistle is primarily beneficial for liver health and detox, and some even use it for hangovers. Milk thistle (Silybum marianum) | Cam-Cancer What is Milk Thistle? Milk thistle is a great supplement for many people, with a lot of research to back up the potential benefits. Milk thistle may also help regulate immune system response. One study did find that milk thistle was effective at increasing milk supply in dairy cows. Silibinin, another flavonoid in milk thistle, has shown several anticancer effects, including the ability to modulate cell signaling, proliferation, cell death (apoptosis), invasion, metastasis, and angiogenesis (development of blood . If given within 24 hours, it significantly reduces the risk of liver damage and death. Inhibition of human carcinoma cell growth and DNA ... An older study found that milk thistle extract had a positive effect on immune response in humans. Large-scale, properly-designed studies are needed. Milk Thistle a Proven Cancer-Fighter and Liver-Supporter 12 Benefits Of Milk Thistle + Its Synergy With Glutathione Breast Cancer Authority on breast cancer health, wellness and recovery through personal shares, complementary therapies, gardening and much more. Based on silymarin's unique characteristics, its application in chemotherapy combined with doxorubicin can be effective to enhance the efficacy together with a reduced toxicity on normal tissues. A University of Colorado Cancer Center study recently published in the journal PLoS One pinpoints the compounds derived from milk thistle that best kill cancer cells directly and restrict tumors' ability to grow . Breast Cancer Authority. A dry extract of milk thistle in the form of a powder was encapsulated with 400 mg per capsule of milk thistle standardized to 80% silymarin. If you have any condition that might be made worse by exposure to estrogen, don't use these extracts. Milk thistle and extracts of milk thistle, such as silymarin, are rich in antioxidants and may have some medical uses. Though there is more research required in humans, this sure is an encouraging step . Research is exploring silymarin and milk thistle and their potential use as a breast cancer treatment alongside traditional therapies to either protect cells or . The role of milk thistle extract in breast carcinoma cell line (MCF-7) apoptosis with doxorubicin Breast cancer is the most commonly diagnosed invasive malignancy and first leading cause of cancer-related deaths in Iranian women. My Oncologist changed my tablets from Arimidex to Femara (I take the generic Letrozole) about 7 weeks ago as I was having lots of side effects on Arimidex. What Is Milk Thistle? Some of the beneficial effects noted include: Milk thistle can interact with some chemotherapy drugs — check with your doctor before you start taking it. Breast cancer is the most commonly diagnosed invasive malignancy and first leading cause of cancer-related deaths in Iranian women. Interestingly, female rats demonstrated decreased breast (mammary) cancer and male rats showed decreased liver cancer with milk thistle extract. Breast Cancer Authority on breast cancer health, wellness and recovery through personal shares, complementary therapies, gardening and much more. ( 94 , 146 , 147) Research shows that milk thistle extracts are nontoxic inhibitors to cancer cell cycles, effectively blocking cancer growth. Whats docs opinion? Although probably best known for its effects on liver health, active compounds from milk thistle may also be beneficial in the following health conditions: (11, 12, 52) Other studies state that milk thistle can induce cancer cell death in the case of colon and breast cancers. A source of the complex flavonoid compound silymarin, which contains silibinin, silybin, silicristin, and silidianin. 6. Estrogens Milk thistle has not been shown to treat or prevent cancer or reduce the side effects of cancer treatment. In humans, milk thistle has been shown to help the chemotherapy drugs, cisplatin and doxorubicin, against ovarian and breast cancer cells. Blessed thistle is known throughout the world for being great for breastfeeding. DO NOT take milk thistle if you are allergic to ragweed, chrysanthemums, marigolds, chamomile, yarrow, or daisies. Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Milk thistle extracts might act like estrogen. Studies of milk thistle have been done in acute lymphoblastic leukemia, prostate cancer, breast cancer, and head and neck cancer (see Question 4 ). Several studies from our laboratory have shown the cancer chemopreventive and anti-carcinogenic effects of silymarin, a flavonoid antioxidant isolated from milk thistle, in long-term tumorigenesis models and in human prostate, breast and cervical carcinoma cells. Registered Office: Fifth Floor, Ibex House, 42-47 Minories, London EC3N 1DY. Milk Thistle has been studied for years for its anti-tumor effects on several types of cancer, especially prostate, lung and liver.This year (2016), however, was the year for this bristly-looking herb to prove its effectiveness on breast cancer. Side effects, toxicity, and interactions Milk thistle may help strengthen a person's immune response and help them fight off infection. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that the herb could allow patints to take potent doses of chemotherapy without damaging . Xeloda can be hard on the stomach, so have him eat as healthy as he can and eat small portions to keep something more frequently in the stomach to help the nausea. Extracts from parts of the plant other than the seeds may increase estrogen levels in the body. It is thought that milk thistle is beneficial for breast milk supply due to its plant estrogens. Milk thistle may also promote breast milk production in mothers producing less milk. And another study focused on silymarin, the plant's active ingredient, and found that the compound led to an 85% increase in the milk supply of nursing mothers.. As a result, hormone-sensitive conditions such as breast cancer, uterine cancer, endometriosis or uterine fibroids may be worsened. Milk thistle is a plant whose fruit and seeds are used for liver and bile duct disorders (see Question 1 ). Milk thistle plants have bright purple flowers, prickly white-veined leaves, and milky sap [ 1 ]. The detoxifying properties of milk thistle are so potent that the herb is used to protect the liver from snake bites. Milk thistle is a great natural resource for detoxing the liver. The FDA has not approved the use of milk thistle as a treatment for cancer or any other medical condition. Silybin has been shown to inhibit growth and induce apoptosis in human breast cancer cells and HER-2/neu overexpressing mammary tumors in a . Randomized, controlled human trials are needed to definitively prove its efficacy against breast cancer and. Since silymarin is composed mainly o … This helps a lot to increase the breast size as various hormones, especially estrogen are processed by the liver. And you can take some Milk Thistle, which has a purifying effect and helps filter and cleanse the liver, even during treatment. However, more research is necessary to prove its effectiveness. It's going to engorge your breast with liquids, which is going to give them volume and firmness. There is some early research that shows how milk thistle can aid healthy weight loss. Ultimately… milk thistle is a safe, natural cancer-fighting substance that can help starve cancer and weaken it from many different angles. I ve just looked up milk thistle on the Memorial Sloan Kettering Cancer Care website. And, while there is only limited scientific evidence that milk thistle can help a nursing mother to make more breast milk, it has been shown to increase milk production in dairy cows. It increases breast milk flow while also maintaining breast health. Milk thistle products are widely available in pharmacies, health food and grocery stores and on the Internet. Silymarin has shown direct anticancer effects against prostate, breast and ectocervical tumor cells, such as slowing cell growth in prostate cancer cells. Sure enough: in one recent study, an herbal conglomerate featuring milk thistle as one of the active participants actually increased estrogen metabolism, effectively reducing the amount of active estrogen by speeding up its clearance from the body. Milk thistle is an herb derived from the milk thistle plant, Silybum marianum.It is used in traditional Chinese medicine to clear heat, remove toxic elements from the body, soothe the liver and promote bile secretions. The Milk Thistle effects on breast (growth) and lactation is nothing new. Potential uses: It is thought that astragalus can improve immunity and liver health and reduce the risk of cancer. In the US, milk thistle is included in the United States Pharmacopoeia-National Formulary. Milk thistle actually works for breast growth. Milk thistle and compounds derived from it are commonly used as herbal supplements for liver problems, but study results are mixed. Milk thistle supplements usually come in the form of capsules or tablets. Lab, animal, and clinical studies suggest compounds in milk thistle may indeed help fight cancer. A 2016 study on an animal model found that milk thistle extract improved the immunity when consumed. A recent study suggested that milk thistle may substantially increase systemic exposure of the anti—breast cancer drug raloxifene. Ady Member Posts: 61 . Milk thistle or silymarin comes from the seeds of the plant it is . Follow the instructions on the package for the correct dose. Milk Thistle Medicinal Uses to Prevent Cancer and Protect Against Harmful Effects of Cancer Therapy. Anecdotally, milk thistle has been used with positive results by breastfeeding mothers in India and Europe for generations. Some of the beneficial effects noted in the many scientific investigations of milk thistle extracts containing silymarin and its major constituent, silibinin, include: Prevention of the expression of genes and enzymes pivotal in breast cancer development Inhibition of breast cancer cell growth and the key pathways that cancer cells use to grow 1. Anecdotally, milk thistle has been used with positive results by breastfeeding mothers in India and Europe for generations. Animal studies have found that milk thistle extract completely counteracts the toxic effects of the mushroom when given within 10 minutes of ingestion. The main active ingredient in milk thistle is silymarin, a . Other areas that are still understudied for the extent of benefits from taking milk thistle are depression, gallbladder disorders, malaria, inconsistency of milk in lactating mothers, varied menstrual issues, among the few. I get asked about this herb all the time, because there's some information on the internet that tells women with breast cancer to avoid milk thistle because of its supposed "estrogenic" and possibly "carcinogenic" (cancer-causing) properties. Silymarin (milk thistle) acts as a free radical scavenger and modulates the enzymes that cause liver cellular damage, fibrosis and cirrhosis. Does anyone take Milk thistle? Does milk thistle help your immune system? Are there any risks? Usual dose: 500 milligrams 3 times per day. Get some Bag Balm at CVS or your local pharmacy and . Side effects from the use of milk thistle or silymarin are mild. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Breast Cancer - As published in the June 2009 edition of Molecular Cancer Therapeutics, Canadian researchers determined that silibinin exhibited anti-proliferative activity on a certain type of . USES: Milk thistle is used to treat alcoholism, hepatitis, drug-induced hepatotoxicity, liver disease, cirrhosis, and food poisoning, as well as to prevent cancer. And, while there is only limited scientific evidence that milk thistle can help a nursing mother to make more breast milk, it has been shown to increase milk production in dairy cows. Could milk thistle help prevent or treat cancer? Milk thistle (Silybum marianum) is a wonderful healing herb, most commonly used to treat liver complaints and to assist with liver detoxification. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Her oncologist has started her on Femara . Milk thistle: A tall thistle (Silybum marianum) having white-veined dark green leaves and large purple flower heads that is native to the Mediterranean region but has become naturalized elsewhere including the United States; also, an extract of milk thistle and especially its seeds that is held to protect the liver from damage or disease." ~ Merriam-Webster Dictionary. [ 5] Some people also take milk thistle to reduce the risk of cancer. In folk medicine Milk Thistle was used for ages to support the milk production in lactating women. 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