Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Arora PN, Dhillon KS, Rajan SR, Sayal SK, Das AL. Don P, Iuga A, Dacko A, Hardick K. Treatment of vitiligo with broadband ultraviolet B and . You have pale skin and sensitivity to cold. Savitha, B. Jayadev, P.A. The age of the cases ranged from 5-62 years, mean age being 26.1 years. 2023 Jan 14;12(2):673. doi: 10.3390/jcm12020673. Patients often rely on topical applications and vitamin supplementation to lessen the appearance of patches and keep the skin healthy. your express consent. BMC Dermatol 2011;11:7. Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. Underwood E. Trace elements in human and animal nutrition. Although the exact etiology of vitiligo is still largely unknown, destruction of melanocytes, cells that produce melanin, a dark pigment responsible for skin color, by the bodys own immune system is considered to be the main cause of vitiligo. Other triggering factors include sunburn, environmental or industrial chemicals, and stress. And taking too much copper could even leave you deficient in zinc, which is also very important. Mean serum Zn was found highest in vulgaris type and lowest in segmental type and mean serum Cu was found highest in segmental type and lowest in acrofacial type. Is Amla Good For Vitiligo? However, despite having a genetic linkage, only 5-7% of children are likely to get vitiligo even if one of their parents has it. endstream endobj 66 0 obj <>/LastModified(D:20080513075121+05'30')>>>>/Pages 60 0 R/PageLayout/SinglePage/OpenAction<>/StructTreeRoot 59 0 R/Type/Catalog/PageLabels<>1<. 0000000845 00000 n Copper supplementation has shown potential as a treatment for vitiligo, and its safety and tolerability profile suggest that it could be a safe and effective therapy. They were found to range from 2.2mol/L (14.3g/dl) to 71.0mol/L (464.23g/dl) in vitiligo cases with a mean of 24.410.8mol/L (159.470.8g/dl). Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin Share this: Like this: Loading. Copper is an important trace mineral that improves metabolic processes in the body and benefits the skin. Indian J dermatol venereal Leprol 2007;73:162-65. IADVL Textbook of Dermatology. I started writing this blog as a way of sharing my own personal story of what it is like to have lived with widespread vitiligo, only to recover most of my pigment again. Karbala J Med 2011;4:1117-21. I bought copper supplements 3 mg just started taking it. Change). Kyriakis KP, Palamaras I, Tsele E, Michailides C, Terzoudi S. Case detection rates of vitiligo by gender and age. These values were statistically insignificant (P-value<0.05) [Figure - 1]. [11 showed the levels of serum Zn were low in the majority of the patients with duration of disease ranging from 2 to 5 years. Change), You are commenting using your Twitter account. Blood was collected from the cases and controls under aseptic precautions and serum was separated which was analysed by Stat Fax 3300 Chemistry Analyzer (by Awareness Technology, INC) thorough photometric analysis. The metanalysis concluded that decreased levels of serum Cu and Zn generally exist in Chinese vitiligo patients. Health Qual Life Outcomes 2003;23:1-58. Koranne RV, Derm D, Sachdeva KG. Copper pathochemistry in vitiligo. Normally, the color of hair and skin is determined by melanin. The study involved measurement of serum zinc and copper levels in vitiligo patients and in normal individuals of comparable age group and sex. An official website of the United States government. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review. While drinking water from a copper vessel is known to be highly beneficial, wearing a copper bracelet is another effective way to increase copper levels in the body. Quality of life in patients with vitiligo. Vitiligo usually develops before age 40, and people suffering with this. Careers. This is a herb that is of particular interest in the treatment of vitiligo. Beats arthritis and inflamed joints. J Pan-Arab League Dermatologist 2004;15:97-105. 3rd edn. However, it is to be highlighted that, normal reference range of Zn was not mentioned in any of these studies. Hope this helps. Please try after some time. The statistical software IBM PASW (Version 22.0) was used for the entire data analysis. Mumbai: Bhalani publishing house; 2008. p. 736-798. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Figure 1 Correlation of Zinc and Copper between cases and controls. Research has increased significantly to more clearly define and plan quicker and more effective treatments for the condition, and there is a belief that genetic and biomedical technology provide promising areas in the development of improved initial understanding, and treatment of, vitiligo. Garg BJ, Saraswat A, Bhatia A, Katare OP. Arch Dermatol 1999;135:407-13. Anti-oxidants are the best treatment for vitiligo as the patches are caused due to oxidative stress. Would you suggest I drink from a copper vessel? More info. Overall, generalized vitiligo was most common, in 70 out of 100 cases (70%), while rest 30 (30%) had localized vitiligo. Is Coconut Oil Good For Vitiligo With or Without Psoralen Treatment? [9] showed that the levels were significantly higher in active vitiligo patients compared to controls. Wearing a band on the wrist is known to show notable improvement in health conditions. Zn and Cu are essential trace elements related to health and disease due to their function as the metal moiety of important enzymes. However, the condition is often stressful, and people may undergo serious depression in some of the worst cases. Aim: To estimate serum and tissue copper levels in vitiligo patients, and to compare with first degree relatives of patients and control group. This low Cu levels may lead to reduced activity of enzyme tyrosinase, which is essential in the process of melanogenesis. Copper deficiencies have been reported to induce hypopigmentation in various animals. 5. The body has a subtle way of absorbing the healing elements of the metal from a bracelet and distributing it to different parts of the body that need it. Disclaimer. Therefore, we undertook a study to evaluate serum Zn and Cu levels in vitiligo. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. Vitiligo is an acquired pigmentary disorder of the skin and mucous membranes. 8th March 2015 In "Causes & Triggers" Minimizes the risk of cancer and anemia. The etiopathogenesis of vitiligo remains unclear. [1] Its prevalence ranges from 0.4% to 2% worldwide and is often reported to be higher in India. 0000001269 00000 n Thus, the complex treatment vitiligo with applicates copper and zinc containing adsorbents normalization of skin pigmenting function." between patient and physician/doctor and the medical advice they may provide. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. Save my name, email, and website in this browser for the next time I comment. Am J Clin Nutr 1996;63:797S-811S. Al-Rubayee WTS. Int J Dermatol 2009;48:328-9. On the similar lines, Helmy et al. Hi thank you for your comment about your vitiligo experience with copper which was an ingredient in Boost. It is still an important part of healing. Applying a corticosteroid cream to affected skin might return color. There are no proven ways to cure vitiligo completely but some natural remedies are known to help improve the appearance of patches and boost repigmentation. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. One study found that copper levels in the serum and skin of patients with vitiligo were inversely correlated with disease severity, suggesting that copper deficiency may play a role in the progression of the disease. (LogOut/ Supplementing with copper can benefit vitiligo patients with deficiency and slow down the progression of the disorder. Here are some of the most effective natural cures for vitiligo. On the other hand, in controls it varied from 24.2mol/L (157.9g/dl) to 67.9mol/L (443.7g/dl) with a mean of 32.29.1mol/L (210.359.3g/dl). Analysis of tissue and serum copper in vitiligo') + "&publicationDate=" + encodeURI ('Jan 1 2021 12:00AM') + "&author=" + encodeURI ('Archana S, Rangappa V, Savitha T, Jayadev B, Kushalappa P, Ashwini P') + "&contentID=" + encodeURI ('PigmentInt_2021_8_1_30_313135') + "&orderBeanReset=true" Thus, Cu plays a role in melanogenesis however, we need to look at the role of Cu in the pathogenesis of vitiligo. Vitamin D increases the rate of melanogenesis by increasing the activity of tyrosinase. Long used for skin health, Aloe Vera supports healthy immune system response and contains essential minerals, including copper. Taking our annual hospital prevalence of vitiligo into account, sample size was calculated and 100 patients of vitiligo (60 males and 40 females with ratio 1:1.22) and 60 healthy age and sex-matched controls (27 males and 33 females with male to female ratio of 1:1.5) were included. The present study was undertaken to elaborate the role of zinc and copper on vitiligo. There are controversial reports as to the changes of serum trace elements, copper (Cu) and zinc (Zn) levels in vitiligo patients. Hence, the levels of these two elements are not interdependent on each other. 0000001772 00000 n [5] They have a role in melanogenesis in catalyzing the rearrangement of dopachrome to form5,6-dihydroxy indole-2 carboxylic acid (DICA) and enhancement of eumelanin polymer formation from monomers. Generalized vitiligo, in which patches appear on many parts of the skin. Many people get a healthy amount of copper by drinking a . Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. Out of 100 cases, as compared to the reference range, serum Zn level was increased in 58 (58%), normal in 41 (41%), and low in the remaining 1 (1%) case, whereas in the control group, it was increased in all 60. Unite For Vitiligo will not be liable for any losses, injuries, or damages arising from its display or use. Karbala J Med 2011;4:1117-21. The distribution of the mean serum levels Zn and Cu was significantly different between the cases and controls (p < .001). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This unusual stretch FIXES your back pain (feel less pain by tomorrow), Embracing Yourself: Dealing with Negative Comments and Misconceptions AboutVitiligo, The Relationship Between Nasal Polyps and GERD: Causes and Treatment Options, One Powerful Spice that Shrinks Nasal Polyps Fast, Gout and Dehydration: Understanding the Connection and Staying Hydrated. Gopal k, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant. A growing body of evidences . doi: 10.1111/dth.12625. Health Qual Life Outcomes 2003;23:1-58. Njoo MD, Das PK, Bos JD, Westerhof W. Association of the Kobner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris. Shajil EM, Agrawal D, Vagadia K, Marfatia YS, Begum R. Vitiligo: Clinical profiles in Vadodara, Gujarat. News-Medical.Net provides this medical information service in accordance Results: Of 60 patients, serum Cu levels in cases were found to be low in 35, normal in 22 and high in 3. Supplementation of B12 and folic acid along with pantothenic acid, a water soluble form of B vitamins, has also shown very promising outcome in removing white patches. Lesions often start on sun-exposed areas [2]. Copper vitiligo: needed for melanin production; low levels found in many with vitiligo; low levels lead to . International Journal of Women's Dermatology4(4):241, December 2018. Students t test or Mann-Whitney U for the quantitative variables with two independent groups and Chi-square/Fishers test was used for statistical significance between qualitative variables. Understanding the Role of Epigenetics in Cancer. Keywords: Indian J Dermatol Venereol Leprol 2013;79:679-85. Shameer P, Prasad P, Kaviarasan P. Serum zinc level in vitiligo: a case-control study. Tyrosinase, a key regulatory enzyme, is a copper (Cu) dependent enzyme. A case-control study was conducted between a period of one and a half years extending from November 2014 to March 2016 where all old and new patients clinically diagnosed with vitiligo, of all age groups within the timeframe were included. The VASI score of cases ranged from 0.25 to 72.60 with the mean VASI score being 9. Though role of Cu in melanogenesis is proven, its role in pathogenesis of vitiligo needs to be studied further. Including this spice regularly in your routine can help restore the pigmentation. On the basis of these functions, it has been long hypothesised that Cu and Zn have a role in pathogenesis of vitiligo and theories like oxidative stress and autocytotoxic theories have been utilised to support their role. Dermatol Clin 2017; 35:235. However, empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by any evidence. $1599 ($2.67/Count) Save 10% with coupon. Conclusions: Our study shows that the significant difference in levels between cases and controls points out the possibility of an important role of Zn and Cu in the pathogenesis of vitiligo, but there is no deficiency of Zn and Cu in the study population, either in the cases or the controls. may email you for journal alerts and information, but is committed The https:// ensures that you are connecting to the More info. During studies, it is found that the copper content of the skin is concentrated mainly in the epidermis. This site uses Akismet to reduce spam. Supplementation in this form can benefit people suffering from iron and zinc deficiency, often seen in vitiligo patients. A combination of copper and magnets is believed to be an effective healing treatment in traditional medicine. https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments. Ashwini Autoimmune disease; EGCG; Ginkgo biloba; Oxidative stress; Polypodium leucotomos; Vitamin D; Vitamins; Vitiligo. These vitamins act as antioxidants and prevent epidermal oxidative stress, which is considered as a causative factor for premature destruction of melanocytes. THE EFFECT OF COPPER IN VITILIGO' BERTRAM SHAFFER, M.D. In our study, mean serum levels of Cu were significantly higher in cases than in controls. Analysis of tissue and serum copper in vitiligo By continuing to browse this site you agree to our use of cookies. Related Is your skin being bleached? Ongoing studies, including those in our lab, are aimed at understanding how this process works. When minerals get absorbed into the skin, they get into the bloodstream directly without getting digested in the stomach like with oral supplements. 2019 Jul;32(4):e12625. Thus, Cu plays a role in melanogenesis however, we need to look at the role of Cu in the pathogenesis of vitiligo. However, it is to be noted that the studies included in this meta-analysis belong to different regions in China and some of the studies themselves mention the variability in the levels due to geographical area and dietary habits. These were not on any oral Zn and Cu supplements. Int J Dermatol 1988;27:676-81. The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical. . Beta carotene is a precursor form of vitamin A with immense antioxidant activity. Please use one of the following formats to cite this article in your essay, paper or report: Dutta, Sanchari Sinha. eCollection 2021. Out of 100 cases, serum Cu level was increased 78 cases (78%), normal in another 21 (21%) and low in none, whereas in the control group, it was normal in 21 out of 60 (35%), increased in 38 (63.33%) of them, and low in 1 subject. Arch Dermatol 2004;140:677-83. Genova D, Bozhkov B, Zlatkov NB. Hence, it is worth checking if the skin disorder can be slowed down with consuming water stored in a copper vessel. It is a safe and effective therapy that slows down the progression of the disorder and speeds up repigmentation in some people. Z Hautkr 1987;62:1064, 9-72, 75. Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Br J Dermatol 1973;89:207-9. Some people report their patches getting less visible with the use of copper bracelets while some others even noticed their patches disappearing with long-term use. %PDF-1.7 % A second explanation of the metabolic disorders in vitiligo might be the role of eventual inhibitor(s) discussed by Fitzpatrick and coll13. Journal of the Indian Medical Association 1961;37:593-7. Hence, always consult your doctor for the appropriate dosages. Majority of the cases, 60 (60%) had vitiligo vulgaris, followed by focal type (22 cases, 22%), acrofacial (10, 10%), segmental (7, 7%) and mucosal vitiligo (1, 1%). Vitiligo: a part of systemic autoimmune process. The mean serum Zinc was low whereas Cu was higher when compared to controls but the actual range of levels of Zn and Cu from patients and controls were much higher than the reference range. Oxid Med Cell Longev. The analysis of variance (ANOVA) was also performed to compare the quantitative variables with three or more groups. Stable Vitiligo was found in 32 out of 100 cases (32%) and unstable in 68 cases (68%). Change), You are commenting using your Facebook account. The 95% confidence range for Zn and Cu was calculated using the reference range [Table - 1] for these variables. [12] also observed lower levels in patients than in controls but this wasnt statistically significant. Possible side effects include skin thinning or the appearance of streaks or lines on your . Researchers have been suggesting that vitiligo may be a result of autoimmunity, genetic, oxidative stress or neural causes. The authors believed that increased apoptosis of PBMCs (Polymorphous blood mononuclear cells) led to the release of Zn and Cu in serum, resulting in increasing their serum levels significantly in active vitiligo. Although the exact cause of vitiligo is unknown, researchers have suggested that multiple factors, including genetics, oxidative stress, and autoimmune processes, may contribute to its development. 2018 Apr;94:234-239. doi: 10.1016/j.yrtph.2018.02.008. For more information, please refer to our Privacy Policy. [8] noted that Zn levels were increased in the patients than controls, but the change wasnt statistically significant. While experiment- This type of cream is effective and easy to use, but you might not see changes in your skin's color for several months. The role of oral supplements, including vitamins, minerals, and botanicals, is increasingly being investigated as adjuncts to conventional medical treatment due to their antioxidant and immunomodulatory activity. Zeng Q, Yin J, Fan F, Chen , Zuo C, Xiang Y. Saleem MA, El-Raheem TA, Aboraia NM. and transmitted securely. Copper bracelets with magnets are popular for treating vitiligo and other disorders. The correlations between the quantitative variables were assessed by scatter plots first and then Pearsons or Spearmans correlation coefficients were calculated. http://www.vitiligostore.com/boost-tanning-supplement.html "Vitamin Supplementation for Vitiligo". Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). Al-Rubayee WTS. Of the . 0000001394 00000 n The study found that 64% of participants experienced an increase in skin color, and the treatment was well-tolerated with no adverse effects reported. This illustrates coppers effects in managing vitiligo by stimulating melanin and repigmenting the skin. The initial observation dealing with the action of copper in this respect was an incidental finding made by Keil and Nelson (1) in 1931. Moreover, vitiligo may co-occur with other autoimmune disorders, such as hypo- or hyper-thyroidism, diabetes, adrenocortical insufficiency, rheumatoid arthritis, and pernicious anemia. In: valia RG, Valia AR, eds. News-Medical. Mean duration was 6.7 years. Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). Or fastest delivery Wed, Oct 26. Segmental vitiligo, where patches appear only on one side of the body. 2022. It also has antioxidant properties that prevent free radicals and ions from raising toxicity. Required fields are marked *. Depending on the locations of patches on the body, vitiligo can be divided into three main categories: The diagnosis mainly depends on evaluating patients medical history as well as their family history of vitiligo incidents. Indian J Dermatol Venereol Leprol 1978;44:281-85. Wolters Kluwer Health, Inc. and/or its subsidiaries. And, so far the exact cause and subsequent development of vitiligo are not fully understood. But, it has been established that copper is another cofactor in melanin production, and many patients with vitiligo are found low in it. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. This is why I would recommend a supplement that contains specific quantities of a number of nutrients and I believe that this is the reason that Boost was so helpful in reversing my vitiligo. Several traditional and herbal treatments have shown promising results among Vitiligo sufferers. So I []. Enter your account data and we will send you a link to reset your password. [3], Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. 2022 Jan 29;14(3):591. doi: 10.3390/nu14030591. Vitiligo. In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research. amino acids. Zheleva A, Nikolova G, Karamalakova Y, Hristakieva E, Lavcheva R, Gadjeva V. Regul Toxicol Pharmacol. Please enable it to take advantage of the complete set of features! Molokhia MM, Portnoy B. Trace elements and skin pigmentation. Addison disease, copper deficiency, parasitosis, and diabetes mellitus. Narang, Isha MDa; Barman, Krishna Deb MDa; Lali, Pramod MDb; Sahoo, Bijaylakshmi MDa, aDepartment of Dermatology, Leprology and Venereology, Maulana Azad Medical College, New Delhi, India, bDepartment of Biochemistry, Leprology and Venereology, Maulana Azad Medical College, New Delhi, India. It appears that rhododenol, an active ingredient in the product that is also a phenol that resembles tyrosine, is responsible for inducing vitiligo in those that used the product. Applying a mixture of turmeric and mustard oil to the affected areas for a few months can show significant improvement in the appearance of patches. Egypt J Hosp Med 2018;70:273-81. Also, for further studies to evaluate these levels in serum of patients, a normal reference range for the specific population has to be defined and taken into consideration. Garg BJ, Saraswat A, Bhatia A, Katare OP. 0000001861 00000 n A Systematic Review of Nutrition, Supplement, and Herbal-Based Adjunctive Therapies for Vitiligo. Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation.
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