Epub 2020 Sep 8. Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, 915 W State St., West Lafayette, IN, 47907 USA. Inhibitors of vancomycin-resistant enterococcus in J Med Chem. During her undergraduate work she performed research in the lab of Joseph Tanski investigating sulfur heterocycle and thioaldehyde reactivity. 2017 • Academic All-Big Ten. (2018) North American Colleges and Teachers of Agriculture. Epub 2017 Nov 16. Collin is from Munster, IN. Chojnacki M, Cao X, Young M, Fritz RN, Dunman PM, Flaherty DP. Xufeng is from Shanghai, China. Hewitt CS, Krabill AD, Das C, Flaherty DP. PubMed PMID: 32681604. As part of pharmacy training, Jason worked in cleanrooms compounding and preparing drugs including antibiotics and radiopharmaceuticals. 2016, 12, 1023 - 1030. Ryan has also been awarded a two-year fellowship from the, her Bachelors of Science in Biochemistry and Molecular Biology from Bob Jones University. He then moved San Antonio and pursue post-bass research in the lab of Dr. Sushma Ramsinghani at Feik School of Pharmacy. Here he worked on the development and synthesis of novel PARG inhibitors. Teacher Educator Award. Heine Pharmacy Building West Lafayette, IN 47907 (913) 944-1845 dflaher@purdue.edu Education 2005 - 2010 University of Nebraska Medical Center Ph.D. in Pharmaceutical Science, emphasis on medicinal chemistry Purdue Center for Cancer Research, Hanson Life Sciences Research Building, 201 S University St., West Lafayette, IN, 47907 USA Dr. Watts lab has extensive expertise studying the pharmacology of adenylyl cyclases (AC) and has shown that AC1 is a potential target to treat inflammatory pain. We are also incorporating protein engineering methods to develop Ubiquitin variants that selectively bind to UCHL1 over all other DUBs. While there Chad worked as an undergraduate research in the labs of Dr. Lisa Prevette and Dr. Thomas Marsh. She is currently a Junior and pursuing a Bachelor of Science in Pharmaceutical Science. This class of enzyme is heavily involved in signaling pathways to turn on/off processes, control cellular trafficking, and sending proteins to degradation through the ubiquitin-proteasome system. He is currently a Junior and pursuing a Bachelor of Science in Pharmaceutical Sciences. Collin recently graduated from Purdue with a Bachelor of Science in Pharmaceutical Sciences in 2019. PubMed PMID: 32865982. Aaron is now a post-doctoral research associate in the lab of Dr. Zhong-Yin Zhang at Purdue University. Daniel Flaherty is a professor in the Pharmacy department at Purdue University - West Lafayette - see what their students are saying about them or leave a rating yourself. Sort by citations Sort by year Sort by title. Edward Knaus and Frank Wuest. *Data image borrowed from Brust et al, Sci Signal, 2017, 10, eaah5381, Organic chemistry, structure-based drug design, molecular modeling, biochemical analysis, covalent inhibition. The Flaherty Lab pursues projects to validate novel therapeutic targets for the treatment of infectious disease, chronic pain, and cancer. Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain. Starting from molecules with these known properties significantly shortens the time to the clinic. in Biochemistry from the University of St. Thomas in St. Paul, MN. She received her B.Sc. Daniel Flaherty is the Assistant Professor at Purdue University based in West Lafayette, Indiana. Chad S Hewitt 1 , Aaron D Krabill 1 , Chittaranjan Das 2 3 , Daniel P Flaherty 1 3 4 Affiliations 1 Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States. E-mail: dflaher@purdue.edu. He performs recombinant protein expression and purification, biochemical assays and X-ray crystallography for ligand bound structures. Cited by. Dept. PubMed PMID: 32787141. Weiwei is from Zhengzhou in Henan Province, China. Purdue University. Congruent Release of Drug and Polymer from Amorphous Solid Dispersions: Insights into the Role of Drug-Polymer Hydrogen Bonding, Surface Crystallization, and Glass Transition. Chembiochem.2019 Aug 26;. While at DePauw Aaron studied the toxicity of novel epoxyketone compounds. Daniel P. Flaherty Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States More by Daniel P. Flaherty “Antibiotic resistance is very complicated,” Dr. Seleem said. Aaron joined the Flaherty Lab in Fall 2015 where is pursuing novel covalent small molecule inhibitors of UCHL1. He received his Doctor of Pharmacy from St. Louis College of Pharmacy. She received her PhD in chemistry at Southern Methodist University, under the supervision of Prof. Alex Lippert. He research is focused on design, synthesis and testing of small molecules in pursuit of best-in-class inhibitors to probe this family of enzymes. His PhD work focused on understanding the structural differences among M1 class amino peptidases and development of novel inhibitors. Upon receiving her B.S. Chojnacki M, Cao X, Young M, Fritz RN, Dunman PM, Flaherty DP. The same class of molecules engage different targets in each pathogen. Trainees in the Flaherty lab acquire hands on experience in many of these areas to provide a holistic drug discovery training experience. Her research is focused on repurposing an FDA-approved drug scaffold with potent anti-N. gonorrhoeae activity and exploring the structure-activity relationship of this class of molecules. Molly joined the Flaherty Lab in Fall 2019 where she is working on drug discovery for anti-Neisseria gonorrhoeae agents. Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases. She performs screening, analog design and synthesis, crystallography, and biochemical assays on the S. aureus RnpA project. See how Purdue never stops in the persistent pursuit of the next giant leap at purdue.edu. Optimization of 4-Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance. Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus. She held two previous postdoctoral positions in organic and medicinal chemistry at the University of Alberta under the direction of Drs. Cited by. We apply these approaches to the following projects that are currently in progress in the lab: Ribonuclease P (RNAse P) is a ribozyme that has long been known to process pre-tRNA in bacteria species via cleavage of the 5' leader sequence. She designs and synthesizes new analogs for the drug repurposing versus VRE project and she was awarded the Purdue Office of Undergraduate Research Scholarship. PubMed PMID: 29105342; PubMed Central PMCID: PMC5808564. Epub 2018 Nov 16. (2017) Purdue University. Name: Daniel P. Flaherty: Title: Assistant Professor of Medicinal Chemisry and Molecular Pharmacology: Type: Faculty: Member of: MCMP Department: Room: RHPH 406B She contributed to the Cayman team by writing an article for, Xufeng is from Shanghai, China. • Did not play. Ryan joined the Flaherty Lab in Fall of 2019 where he is working on covalent probe development to better understand the role UCHL1 plays in cancer and other diseases. ChemMedChem. He joined the MCMP graduate program in fall of 2016. Year; Polyfluorinated bis-styrylbenzene β-amyloid plaque binding ligands. Epub 2017 Jan 16. Biochemical and cellular characterization of a cyanopyrrolidine covalent Ubiquitin C-terminal hydrolase L1 inhibitor. lab of Dr. Zhong-Yin Zhang at Purdue University. This project is currently funded by the NIH through 2024 (R01AI148523). of Medicinal Chemistry and Molecular Pharmacology. UCHL1 expression correlates well with tumor size and invasiveness and further studies have shown that it appears to regulate pathways leading to metastasis. Inhibitors of vancomycin-resistant enterococcus in J Med Chem, Inhibitors of Neisseria gonorrhoeae carbonic anhydrase. Congruent Release of Drug and Polymer from Amorphous Solid Dispersions: Insights into the Role of Drug-Polymer Hydrogen Bonding, Surface Crystallization, and Glass Transition. Inhibitors of Acinetobacter baumannii adaptive efflux, Xufeng is now a Research Scientist at Moffit Cancer Center in Tampa, FL. degree Katrina joined Cayman Chemical in the Forensics Division where she was involved in synthesizing analytical reference standards of phytocannabinoids. Antibiotics (Basel). His research focuses on validating novel therapeutic targets for treatment in infectious disease, cancer, and neurodegenerative disease. Department of Medicinal Chemistry and Molecular Pharmacology. in Medicinal Chemistry from the same University where she studied SAR of flavone derivatives against CDK1. Analogs to the Watts lab for testing and any prioritized molecules move to in vivo studies in Dr. Van Rijn's lab. Daniel P. Flaherty 575 Stadium Mall Dr Ph.D. in pharmaceutical science with expertise in medicinal chemistry . Starting from a molecule that has already gained FDA-approval provides our team with hits that are already known to be safe and possess desirable drug-like pharmacokinetic and physicochemical properties. In the Flaherty lab Weiwei's primary project will be the optimization of inhibitors against vancomycin-resistant enterococcus. (2019) Purdue University. Articles on any aspect of structural biology, including structures determined using high-throughput methods or from iterative studies such as those used in the pharmaceutical industry, are welcomed by the journal. He is now an assistant professor in the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University with interests in developing small molecule inhibitors using structure-based design for under-explored biomolecular targets. Her thesis project focused on the design, synthesis and application of chemiluminescent probes to detect and quantify nitroxyl and other gasotransmitters in cells. Katrina's undergraduate research was in conduction with Cayman Chemical focused on using click chemistry and triphosgene-mediated coupling to develop inhibitors for diacylglycerol lipase beta. The overall goal is for students to have a well-rounded experience and understanding of small molecule structure-based design and be carry out multiple facets of the process as they move on in their research careers. Epub 2018 Sep 19. Welcome to ChemBioLinks, a carefully curated directory of investigators working along the interface of chemistry and biology. An equal access/equal opportunity university, NIH Drug Discovery for the Nervous System Study Section (. Amanda is from Boca Raton, FL. Writer: Chris Adam, 765-588-3341, cladam@prf.org Sources: Daniel Flaherty, dflaher@purdue.edu Kaur J, Cao X, Abutaleb NS, Elkashif A, Graboski AL, Krabill AD, AbdelKhalek AH, An W, Bhardwaj A, Seleem MN, Flaherty DP. Drug-repurposing is a method in which researchers use an FDA-approved drug for an indication that the drug was not originally approved for. Katrina joined the Flaherty Lab Fall 2020 where she is working on the development of novel carbonic anhydrase inhibitors to target the vancomycin-resistant enterococcus. Member of the American Chemical Society, Organic and Medicinal Chemistry Divisions. PubMed PMID: 30472604; PubMed Central PMCID: PMC6310635. Undergraduates are able to apply what they have learned in organic chemistry and biochemistry toward active medicinal chemistry projects. Daniel P. Flaherty. Jason joined the the Flaherty Lab in Fall of 2017 where he works in a collaboration with Dr. Watt's lab to develop novel adenylyl cyclase 1 inhibitors. Department: Department of Medicinal Chemistry and Molecular Pharmacology (MCMP) Overview. Mol Pharm. Sort. Writer: Chris Adam, 765-588-3341 , cladam@prf.org Sources: Daniel Flaherty, dflaher@purdue.edu Postdoctoral Research Associate: 2016 - 2018, In the Flaherty Lab Lisha's project focuses on validating RNA metabolism pathways as therapeutic targets for antibiotic development. Deubiquitinating enzymes have become increasingly popular drug targets for a variety of indications. (2017) Association of Public and Land-Grant Universities. He received is Bachelors of Arts in Chemistry and a minor in Biology from Carroll College. She received a B.S. PubMed PMID: 28119024; PubMed Central PMCID: PMC5296257. 2018 • Academic All-Big Ten. Identification of Small Molecule Inhibitors of, Optimization of a 1,3,4-oxadiazole series for inhibition of Ca, Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus. He has held one previous post-doc position in the lab of Dr. Jennifer Golden at University of Wisconsin-Madison where he worked on optimization of inhibitors against Venezuelan and eastern encephalitis virus. Jatinder is from Batala in the Punjab state in northern India. variants selective toward UCHL1 that will ultimately be used to probe the enzyme. Advance your research. Amanda recently graduated from Purdue with a Bachelor of Science in Pharmaceutical Science in 2019. Katrina is from Tecumseh, MI. Medicinal Chemistry. degree Katrina joined Cayman Chemical in the Forensics Division where she was involved in synthesizing analytical reference standards of phytocannabinoids. PubMed PMID: 30279314; PubMed Central PMCID: PMC6168776. He received a B.S. ... Amanda recently graduated from Purdue with a Bachelor of Science in Pharmaceutical Science in 2019. Colquhoun JM, Ha L, Beckley A, Meyers B, Flaherty DP, Dunman PM. 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Dr. van Rijn RM, Watts VJ, Flaherty DP for diacylglycerol lipase beta in as a associate...
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